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2.4.1 Oral Administration
Tamsulosin is administered by oral, intradermal (subcutaneously), intraperitoneal (under the skin on outside of buttocks) or aerosol methods, including sublingual, transdermal-nasal (transdermal and mucosal-nasal) (patch, inhaler sprays) spray products. It is not expected that any particular route of administration will have an advantage over another in the treatment of T. vaginalis; however, certain products may be better suited to different
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Table I. Indications and Clinical Studies for the Use of Tamsulosin. Route Administration Dosage (mg/day) Doses Duration of Therapy Tamsulosin 1-6 mg sublingually or parenterally; intradermally in 1-8 g oral solution with water once daily for one day 2 g in 2-4 pharmacy perth au oral solution once daily for one day
2.4.2 Oral or Rectal Administration
To evaluate a new oral formulation, 2-week placebo-controlled, double-blind, randomized study with 15 subjects was conducted by Shumaker et al[1]. After completion of dose 4, Tamsulosin 4 mg was given with 200 mg/day of metronidazole to exclude possible gastrointestinal toxicity. This trial was stopped at 2 weeks, due to an increased incidence of severe side effects. These included dysuria and nausea (which improved at day 14) and ataxia (which did not change at day 10).
On day 3, patients were randomized in a double-blind, randomized, balanced, cross-over design to receive either 200 mg of Tamsulosin once daily or 4 mg daily. For the first five days of study, the patients were treated under identical conditions including placebo. On day 7, they were given 50 mg of Tamsulosin 4 orally, administered as a bolus followed by 150 ml of a 50% solution water and the other 50% of solution
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For each of the following seven days, a single oral administration of 50 mg Tamsulosin and 150 ml of water was given. From day 7 until 14, Tamsulosin was given at 50 mg three times daily; on day 14 for T. vaginalis study, Study and GBS Study. Patients were instructed to avoid sex, suppositories, and antibiotics during this treatment period and all vaginal suppositories were discontinued in order to avoid potential contamination with Tamsulosin. The suppository, as well any other potentially contaminated product, were discarded. At each dose, a 2 g sublingual solution of Tamsulosin was prepared and given to patients. A sublingual suppository was provided daily and used until discharge occurred.
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